Molecular Mechanisms of Nickel Allergy

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Molecular Mechanisms of Nickel Allergy.

Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the fi...

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[Mechanisms of nickel allergy].

Nickel allergy constitutes a serious health problem of modern societies. Hypersensitivity to this metal is found in 13% adults and 8% children. Risk factors for nickel allergy are: female gender and early exposure to nickel, e.g. piercing. Various mechanisms of inducing nickel allergy are possible, which is also reflected in the different clinical pictures. Nickel can induce allergic reaction i...

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Molecular mechanisms of nickel carcinogenesis.

Nickel treatment of intact cultured cells oxidized dichlorofluorescin to a fluorescent product indicating that nickel elevated the level of oxidants in cells. Nickel also caused an increase in crosslinking of amino acids to DNA and these complexes did not appear to involve the direct participation of Ni2+. Histidine, cysteine and tyrosine were prominent among the amino acids crosslinked to DNA....

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Systemic nickel allergy syndrome

Methods Demonstrate SNAS which is characterized by contact dermatitis to nickel and systemic reactions after ingestion of rich foods nickel.We evaluated adult patients with ages between 18 and 65 years, positive patch test for nickel, grades 3 and 4, and who had symptoms suggestive of SNAS.These patients had eczematous lesions of contact dermatitis did not disappear. That even with the exclusio...

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A study of nickel allergy.

N ickel is a potentially allergenic material. It is one of the most common causes of allergic contact dermatitis, particularly in women. l-5 Nickel can also be considered an occupational allergen. Nickel contact dermatitis is common among industrial workers, especially in those industries that use nickel as a raw material. It has been demonstrated that U.S. S-cent coins contain approximately 25...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2016

ISSN: 1422-0067

DOI: 10.3390/ijms17020202